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Hair Loss Treatments

How Does The Big 3 Stop Hair Loss?

The big 3 refers to Propecia (finasteride), Rogaine (minoxidil), and Nizoral (ketoconazole) shampoo. Using all of these treatments in conjunction is called 'the big 3.' However, many hair loss sufferers choose which treatment they feel comfortable with using and don't understand why it's necessary to use all three of these treatments to maximize effectiveness. In this article, we will be going over why the big three are effective. 

Three Elements Trigger Hair Loss

To understand how and why the big 3 effectively treats hair loss, you must know the three key factors contributing to genetic hair loss.

Factor #1- Scalp Inflammation: An inflamed scalp contributes significantly to hair loss. To effectively treat hair loss, you have to treat scalp inflammation. 

Factor #2- Shortened Anagen (growth) Cycle: Hair follicles go through three cycles, the anagen (growth) phase, the catagen (transition) phase, and the telogen (resting) phase. If you're experiencing hair loss, your hair follicles will frequently enter the dormant phase. You will have fewer hair follicles in the growth phase at any given time, which contributes to a thinner head of hair. 

Factor #3- Androgen Sensitivity- It is no secret that the androgen DHT is responsible for attacking vulnerable hair follicles and shrinking them until they eventually stop growing. That is why the most effective treatment for hair loss is reducing the androgen activity on the scalp. 

How Does The Big 3 Work

The big three treat every aspect of hair loss. For example, studies have shown that Nizoral shampoo reduces scalp inflammation, which helps stop hair loss. Minoxidil keeps the hair follicles in the anagen growth phase longer on the scalp, and finasteride inhibits the 5-alpha reductase enzyme, which converts testosterone into DHT. 

When combining all three of these treatments, you are fighting androgenic alopecia from every angle. Now, you don't necessarily have to use the brand name of these drugs or even use the oral and topical versions. For example, you can substitute oral finasteride for topical finasteride. You could substitute topical minoxidil for oral minoxidil. You can also substitute Nizoral shampoo for another shampoo that carries ketoconazole. 


The most effective way to treat hair loss is to attack it from each angle. You must treat scalp inflammation, shorten hair follicle life cycle, and block DHT from attacking the hair follicles. If you are into homeopathic treatments, you can use other alternatives, but keep in mind the most effective drugs mentioned above. To learn about the best treatments and surgical hair restoration, visit our popular hair loss community